ABSTRACT
Objective :To explore influence of collective exercise motivation mode on quality of life (QOL) and prog-nosis in patients with coronary heart disease (CHD).Methods :A total of 116 CHD patients were randomly and e-qually divided into routine guidance group (received routine discharge guidance ) and exercise motivation group (re-ceived collective exercise motivation mode ).Seattle angina questionnaire (SAQ) was used to evaluate QOL ,thera-peutic compliance scale was used to assess therapeutic compliance ,and clinical prognosis was evaluated by major ad-verse cardiac events (MACE).Results :Compared with routine guidance group after intervention ,there were signif-icant rise in total SAQ score [ (52.4 ± 4.5) scores vs .(65.9 ± 5.4) scores] and therapeutic compliance (65.5% vs. 82.8%) ,and significant reduction in incidence rate of MACE (17.2% vs.5.2%) in exercise motivation group ,P＜0.05 or ＜0.01. Conclusion : Collective exercise motivation model can significantly improve quality of life ,thera-peutic compliance and prognosis in patients with coronary heart disease ,which is worth extending .
ABSTRACT
@#BACKGROUND: Many studies have showed that apoptosis of endothelial cells plays a curial role in the progress of sepsis. But the role of simvastatin in apoptosis of endothelial cells induced by sepsis is not clear. The present study aimed to investigate the role of simvastatin in apoptosis of endothelial cells induced by sepsis and its mechanism. METHODS: Human umbilical vein endothelial cells (HUVECs) were randomly divided into three groups: control group, sepsis serum intervention group (sepsis group) and simvastatin+sepsis serum intervention group (simvastatin group). After 24-hour incubation with corresponding culture medium, the relative growth rate of HUVECS in different groups was detected by MTT assay; the apoptosis of HUVECs was detected by Hoechst33258 assay and flow cytometry; and the expression of the Bcl-2 and Bax genes of HUVECs was detected by PCR. RESULTS: Compared with the sepsis group, HUVECs in the simvastatin group had a higher relative growth rate. Apoptotic HUVECs decreased significantly in the simvastatin group in comparison with the sepsis group. Expression of the Bcl-2 gene in HUVECs decreased obviously, but the expression of the Bax gene increased obviously after 24-hour incubation with sepsis serum;however, the expression of the Bcl-2 and Bax genes was just the opposite in the simvastatin group. CONCLUSIONS: Our study suggests that simvastatin can inhibit apoptosis of endothelial cells induced by sepsis through upregulating the expression of Bcl-2 and downregulating Bax. It may be one of the mechanisms for simvastatin to treat sepsis.